Responses to Trinitrophenyl-ovalbumin Drug-induced Type 1 versus Type 2 Selective Requirement for Cd40-cd154 In

Trinitrophenyl - Ovalbumin Drug - Induced Type 1 Versus Type 2 Selective Requirement for CD 40 - CD

Responses to Trinitrophenyl - Ovalbumin Drug - Induced Type 1 and Type 2 Immune CD 28 / CTLA - 4 - CD 80 / CD 86 Interactions in Differential Requirement for

The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo.

We used signal transducer and activator of transcription 4 (STAT4) and STAT6 gene knockout (-/-) mice as recipients of fully mismatched cardiac allografts to study the role of T-cell costimulatory pathways in regulating allogeneic T-helper 1 (Th1) versus Th2 responses in vivo. STAT4(-/-) mice have impaired Th1 responses, whereas STAT6(-/-) mice do not generate normal Th2 responses. Cardiac allo...

Trinitrophenyl - Ovalbumin Drug - Induced Type 1 and Type 2 Immune CD 28 / CTLA - 4 - CD 80 / CD 86 Interactions in Differential Requirement for

Characterization of the CD154-positive and CD40-positive cellular subsets required for pathogenesis in retrovirus-induced murine immunodeficiency.

Genetically susceptible C57BL/6 (B6) mice that are infected with the LP-BM5 isolate of murine retroviruses develop profound splenomegaly, lymphadenopathy, hypergammaglobulinemia, terminal B-cell lymphomas, and an immunodeficiency state bearing many similarities to the pathologies seen in AIDS. Because of these similarities, this syndrome has been called murine AIDS (MAIDS). We have previously s...